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Telomeric impact of conventional chemotherapy
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 411-417 doi: 10.1007/s11684-013-0293-z
The increased level of chromosome instability in cancer cells, leading to aneuploidy and gross chromosomal rearrangements, is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies (CT) kill cells by inducing a non-tolerable rate of DNA damage. A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs. These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres. In agreement with this view, accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT (stem cell transplantation) or non-myeloablative CT. However, almost nothing is known on the consequences of this shortening in terms of telomere stability, senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors (cognitive defect, fertility impairment, etc.). In this article, we propose: (1) telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies.
关键词: telomere antineoplasic drugs conventional chemotherapies
《能源前沿(英文)》 doi: 10.1007/s11708-023-0907-3
关键词: oxygen reduction electrocatalysis Pt single-atom catalysts conventional Pt-based catalysts design thoughts and synthesis metal-support interactions
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 406-410 doi: 10.1007/s11684-012-0217-3
The esophagus is perfused directly by prominent arteries and may provide a more consistent tissue source for pulse oximetry. The goal of this study was to evaluate the sensitivity and accuracy of an esophageal pulse oximetry probe on patients during controlled hypoxemia in comparison to measurements obtained with conventional pulse oximetry (SpulseO2). Forty-five ASA I–II adult patients were included in this prospective observational study. Nellcor digital oximetric probes were placed on finger tips for SpulseO2 before anesthesia. After tracheal intubation, an esophageal probe was placed in the lower segment of the esophagus for esophageal oximetric monitoring (SoesO2). All patients were disconnected from the breathing circuit to establish a controlled hypoxemia, and were re-connected to the breathing circuit and ventilated with 100% oxygen immediately when SoesO2 dropped to 90%. Matched SoesO2 and SpulseO2 readings were recorded when SoesO2measurements were at 100%, 95%, 90% and the lowest reading. The time for SoesO2 and SpulseO2 to drop from 100% to 95%, 90% and return to 100% was recorded. Oxygen saturation from arterial blood samples (SartO2) was also measured at each time point respectively. The linear correlation coefficient of the regression analysis between SartO2 and SoesO2 was 0.954. The mean±2SD of the difference was 0.3%±4.3% for SoesO2vs. SartO2 and 6.8%±5.6% for SpulseO2vs. SartO2 (P<0.001). The 95% confidence interval for the absolute difference between SoesO2 and SartO2 was 0.3% to 0.7% and 6.2% to 7.4% between SpulseO2 and SartO2. The time to reach 90% saturation measured with SoesO2 was approximately 94 seconds earlier than the SpulseO2 (P<0.001). In conclusion, SoesO2 is more accurate and enables earlier detection of hypoxemia when compared to conventional pulse oximetry during hypoxemia for patients undergoing general anesthesia.
关键词: esophageal pulse oximetry conventional pulse oximetry hypoxemia
《环境科学与工程前沿(英文)》 doi: 10.1007/s11783-021-1483-6
While a growing number of wastewater treatment plants (WWTPs) are being retrofitted from the conventional activated sludge (CAS) process to the membrane bioreactor (MBR) process, the debate on the techno-economy of MBR vs. CAS has continued and calls for a thorough assessment based on techno-economic valuation.
关键词: Membrane bioreactor (MBR) Conventional activated sludge (CAS) Cost-benefit analysis Data envelopment analysis Net profit
Nonlinear experimental response of non-conventional composite steel and concrete connection
Tobia ZORDAN, Bruno BRISEGHELLA
《结构与土木工程前沿(英文)》 2009年 第3卷 第1期 页码 42-49 doi: 10.1007/s11709-008-0058-y
关键词: composite connections nonlinear behaviour hogging moment monotonic tests
Mostafa FAKHARIFAR,Ahmad DALVAND,Mohammad K. SHARBATDAR,Genda CHEN,Lesley SNEED
《结构与土木工程前沿(英文)》 2016年 第10卷 第1期 页码 44-62 doi: 10.1007/s11709-015-0295-9
关键词: FRP ductility confinement seismic shear
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 284-294 doi: 10.15302/J-FASE-2021435
Bioenergy, currently the largest renewable energy source in the EU (64% of the total renewable energy consumption), has sparked great interest to meet the 32% renewable resources for the 2030 bioeconomy goal. The design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop rotations. This study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops, while keeping main feed/food crops, or by substituting food crops with an increase of the crop rotation length. The assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production, with and without tillage, to evaluate their agri-environmental performances (biomass production, nitrogen fertilization autonomy, greenhouse gas emissions and biogas production). The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators, biomass productivity (27% and 20% higher, respectively), nitrogen fertilization autonomy (26% and 73% higher, respectively), methanogenic potential (77% and 41% higher, respectively) and greenhouse gas emissions (15% and 3% higher, respectively). There were no negative impacts of no-till compared to the tillage practice, for all tested variables. The biogas cropping system showed a better potential in terms of agri-environmental performance, although its greenhouse gas emissions were higher. Consequently, it would be appropriate to undertake a multicriteria assessment integrating agri-environmental, economic and social performances.
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 356-360 doi: 10.1007/s11684-015-0404-0
Robotic system has been increasingly used in pancreatectomy. However, the effectiveness of this method remains uncertain. This study compared the surgical outcomes between robot-assisted laparoscopic distal pancreatectomy and conventional laparoscopic distal pancreatectomy. During a 15-year period, 35 patients underwent minimally invasive approach of distal pancreatectomy in our center. Seventeen of these patients had robot-assisted laparoscopic approach, and the remaining 18 had conventional laparoscopic approach. Their operative parameters and perioperative outcomes were analyzed retrospectively in a prospective database. The mean operating time in the robotic group (221.4 min) was significantly longer than that in the laparoscopic group (173.6 min) (P = 0.026). Both robotic and conventional laparoscopic groups presented no significant difference in spleen-preservation rate (52.9% vs. 38.9%) (P = 0.505), operative blood loss (100.3 ml vs. 268.3 ml) (P = 0.29), overall morbidity rate (47.1% vs. 38.9%) (P = 0.73), and post-operative hospital stay (11.4 days vs. 14.2 days) (P = 0.46). Both groups also showed no perioperative mortality. Similar outcomes were observed in robotic distal pancreatectomy and conventional laparoscopic approach. However, robotic approach tended to have the advantages of less blood loss and shorter hospital stay. Further studies are necessary to determine the clinical position of robotic distal pancreatectomy.
关键词: distal pancreatectomy pancreatic neoplasm robotic surgery
Sadegh REZAEI,Asskar Janalizadeh CHOOBBASTI
《结构与土木工程前沿(英文)》 2014年 第8卷 第3期 页码 292-307 doi: 10.1007/s11709-014-0256-8
关键词: liquefaction microtremor vulnerability index artificial neural networks (ANN) microzonation
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
《医学前沿(英文)》 2007年 第1卷 第1期 页码 11-19 doi: 10.1007/s11684-007-0003-9
关键词: development conventional identification elucidation Successful immunotherapy
Hamed MANSOORI, Parviz Rezvani MOGHADDAM, Rooholla MORADI
《能源前沿(英文)》 2012年 第6卷 第4期 页码 341-350 doi: 10.1007/s11708-012-0206-x
关键词: energy efficiency specific energy net return Cobb-Douglas function
Xiaoyan Song,Rui Liu,Lujun Chen,Tomoki Kawagishi
《环境科学与工程前沿(英文)》 2017年 第11卷 第2期 doi: 10.1007/s11783-017-0919-5
关键词: Alkalinity Antibiotics Biofilm Digested piggery wastewater (DPW) Membrane bioreactor
Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA
《环境科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 43-48 doi: 10.1007/s11783-012-0397-8
关键词: ammonia-oxidizing bacteria hydraulic retention time nitrification activity nitrite-oxidizing bacteria population dynamics
Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment
Xiaoyan Song, Rui Liu, Lujun Chen, Baogang Dong, Tomoki Kawagishi
《环境科学与工程前沿(英文)》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0941-7
关键词: Anoxic stress Carbon source Digested piggery wastewater Intermittently aerated SBR (IASBR) Total nitrogen
Xi CHEN,Linjiang YUAN,Wenjuan LU,Yuyou LI,Pei LIU,Kun NIE
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 324-333 doi: 10.1007/s11783-014-0627-3
关键词: aerobic granular sludge completely mixed activated sludge system (CMAS) continuous flow shear force filamentous bacteria polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE)
标题 作者 时间 类型 操作
Oxygen reduction electrocatalysis: From conventional to single-atomic platinum-based catalysts for proton
期刊论文
Esophageal pulse oximetry is more accurate and detects hypoxemia earlier than conventional pulse oximetry
null
期刊论文
Techno-economic characteristics of wastewater treatment plants retrofitted from the conventional activated
期刊论文
Nonlinear experimental response of non-conventional composite steel and concrete connection
Tobia ZORDAN, Bruno BRISEGHELLA
期刊论文
Innovative hybrid reinforcement constituting conventional longitudinal steel and FRP stirrups for improved
Mostafa FAKHARIFAR,Ahmad DALVAND,Mohammad K. SHARBATDAR,Genda CHEN,Lesley SNEED
期刊论文
AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS
期刊论文
Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study
null
期刊论文
Liquefaction assessment using microtremor measurement, conventional method and artificial neural network
Sadegh REZAEI,Asskar Janalizadeh CHOOBBASTI
期刊论文
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
期刊论文
Energy budget and economic analysis in conventional and organic rice production systems and organic scenarios
Hamed MANSOORI, Parviz Rezvani MOGHADDAM, Rooholla MORADI
期刊论文
Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR
Xiaoyan Song,Rui Liu,Lujun Chen,Tomoki Kawagishi
期刊论文
Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional
Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA
期刊论文
Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment
Xiaoyan Song, Rui Liu, Lujun Chen, Baogang Dong, Tomoki Kawagishi
期刊论文